The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomains

Multiple myeloma (MM) is a tumor of plasmablasts/plasma cells (PCs) characterized by the expansion of malignant PCs with complex genetic aberrations in the bone marrow (BM). Recent reports, by us and others, have highlighted the polycomb group (PcG) proteins as potential targets for therapy in MM. T...

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Vydáno v:Oncotarget
Hlavní autoři: Alzrigat, Mohammad, Párraga, Alba Atienza, Majumder, Muntasir Mamun, Ma, Anqi, Jin, Jian, Österborg, Anders, Nahi, Hareth, Nilsson, Kenneth, Heckman, Caroline A., Öberg, Fredrik, Kalushkova, Antonia, Jernberg-Wiklund, Helena
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732762/
https://ncbi.nlm.nih.gov/pubmed/29262596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21909
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