Delineating the distinct role of AKT in mediating cell survival and proliferation induced by CD154 and IL-4/IL-21 in chronic lymphocytic leukemia

The functional significance of AKT in chronic lymphocytic leukemia (CLL) remains unclear. Given the importance of non-malignant T cells in regulating clonal expansion in CLL, we investigated the role of AKT in T cell-mediated cytoprotection and proliferation using an established co-culture system in...

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Vydáno v:Oncotarget
Hlavní autoři: Chapman, Elinor A., Oates, Melanie, Mohammad, Ishaque S., Davies, Barry R., Stockman, Paul K., Zhuang, Jianguo, Pettitt, Andrew R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732702/
https://ncbi.nlm.nih.gov/pubmed/29262536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22292
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