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The Potential of Donor T-Cell Repertoires in Neoantigen-Targeted Cancer Immunotherapy
T cells can recognize peptides encoded by mutated genes, but analysis of tumor-infiltrating lymphocytes suggests that very few neoantigens spontaneously elicit T-cell responses. This may be an important reason why immune checkpoint inhibitors are mainly effective in tumors with a high mutational bur...
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| Publicado no: | Front Immunol |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5732232/ https://ncbi.nlm.nih.gov/pubmed/29321773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01718 |
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