CRISPR-ON-Mediated KLF4 overexpression inhibits the proliferation, migration and invasion of urothelial bladder cancer in vitro and in vivo

Kruppel like factor 4 (KLF4), a transcription factor associated with carcinogenesis and tumor progression, plays an important role in various malignancies. In the present study, we utilized the CRISPR-ON system to upregulate KLF4 expression level and subsequently investigated the effect and mechanis...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Xu, Xin, Li, Jiangfeng, Zhu, Yi, Xie, Bo, Wang, Xiao, Wang, Song, Xie, Haiyun, Yan, Huaqing, Ying, Yufan, Lin, Yiwei, Liu, Ben, Wang, Wei, Zheng, Xiangyi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731936/
https://ncbi.nlm.nih.gov/pubmed/29254226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22158
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