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Metformin induces cell cycle arrest at the G1 phase through E2F8 suppression in lung cancer cells
A target molecule responsible for cell cycle arrest by metformin was discovered using a gene chip array in lung cancer cells and the effect of metformin on E2F8 was assessed. The siRNA-mediated knockdown of E2F8 significantly suppressed G1-S progression while ectopic expression of E2F8 relieved metf...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5731892/ https://ncbi.nlm.nih.gov/pubmed/29254182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21552 |
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