Let-7g suppresses both canonical and non-canonical NF-κB pathways in macrophages leading to anti-atherosclerosis

Transformation of macrophages to foam cells contributes to atherosclerosis. Here, we report that let-7g reduces macrophage transformation and alleviates foam cell apoptosis by suppressing both canonical and non-canonical NF-κB pathways. In the canonical pathway, let-7g inhibits phosphorylation of IK...

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Publicado en:Oncotarget
Autores principales: Wang, Yung-Song, Hsi, Edward, Cheng, Hsin-Yun, Hsu, Shih-Hsien, Liao, Yi-Chu, Juo, Suh-Hang H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731853/
https://ncbi.nlm.nih.gov/pubmed/29254143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18197
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