Human hepatic lipase overexpression in mice induces hepatic steatosis and obesity through promoting hepatic lipogenesis and white adipose tissue lipolysis and fatty acid uptake

Human hepatic lipase (hHL) is mainly localized on the hepatocyte cell surface where it hydrolyzes lipids from remnant lipoproteins and high density lipoproteins and promotes their hepatic selective uptake. Furthermore, hepatic lipase (HL) is closely associated with obesity in multiple studies. There...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cedó, Lídia, Santos, David, Roglans, Núria, Julve, Josep, Pallarès, Victor, Rivas-Urbina, Andrea, Llorente-Cortes, Vicenta, Laguna, Joan Carles, Blanco-Vaca, Francisco, Escolà-Gil, Joan Carles
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731695/
https://ncbi.nlm.nih.gov/pubmed/29244870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189834
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