Real-time acquisition of transendothelial electrical resistance in an all-human, in vitro, 3-dimensional, blood–brain barrier model exemplifies tight-junction integrity

The blood–brain barrier (BBB) consists of endothelial cells, astrocytes, and pericytes embedded in basal lamina (BL). Most in vitro models use nonhuman, monolayer cultures for therapeutic-delivery studies, relying on transendothelial electrical resistance (TEER) measurements without other tight-junc...

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Detalles Bibliográficos
Publicado en:FASEB J
Autores principales: Maherally, Zaynah, Fillmore, Helen L., Tan, Sim Ling, Tan, Suk Fei, Jassam, Samah A., Quack, Friederike I., Hatherell, Kathryn E., Pilkington, Geoffrey J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2018
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731124/
https://ncbi.nlm.nih.gov/pubmed/28883042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700162R
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