A mechanism of cohesin‐dependent loop extrusion organizes zygotic genome architecture

Fertilization triggers assembly of higher‐order chromatin structure from a condensed maternal and a naïve paternal genome to generate a totipotent embryo. Chromatin loops and domains have been detected in mouse zygotes by single‐nucleus Hi‐C (snHi‐C), but not bulk Hi‐C. It is therefore unclear when...

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Publicat a:EMBO J
Autors principals: Gassler, Johanna, Brandão, Hugo B, Imakaev, Maxim, Flyamer, Ilya M, Ladstätter, Sabrina, Bickmore, Wendy A, Peters, Jan‐Michael, Mirny, Leonid A, Tachibana, Kikuë
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730859/
https://ncbi.nlm.nih.gov/pubmed/29217590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201798083
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