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Why do BCL-2 inhibitors work and where should we use them in the clinic?

Intrinsic apoptosis is controlled by the BCL-2 family of proteins but the complexity of intra-family interactions makes it challenging to predict cell fate via standard molecular biology techniques. We discuss BCL-2 family regulation and how to determine cells’ readiness for apoptosis and anti-apopt...

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Bibliografske podrobnosti
izdano v:Cell Death Differ
Main Authors: Montero, Joan, Letai, Antony
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729538/
https://ncbi.nlm.nih.gov/pubmed/29077093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.183
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