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Why do BCL-2 inhibitors work and where should we use them in the clinic?
Intrinsic apoptosis is controlled by the BCL-2 family of proteins but the complexity of intra-family interactions makes it challenging to predict cell fate via standard molecular biology techniques. We discuss BCL-2 family regulation and how to determine cells’ readiness for apoptosis and anti-apopt...
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| Pubblicato in: | Cell Death Differ |
|---|---|
| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5729538/ https://ncbi.nlm.nih.gov/pubmed/29077093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.183 |
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