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Why are there hotspot mutations in the TP53 gene in human cancers?
The p53 gene contains homozygous mutations in ~50–60% of human cancers. About 90% of these mutations encode missense mutant proteins that span ~190 different codons localized in the DNA-binding domain of the gene and protein. These mutations produce a protein with a reduced capacity to bind to a spe...
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| Publié dans: | Cell Death Differ |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5729536/ https://ncbi.nlm.nih.gov/pubmed/29099487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.180 |
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