Twist1 regulates embryonic hematopoietic differentiation through binding to Myb and Gata2 promoter regions

Mechanisms underlying differentiation of embryonic hematopoietic stem/progenitor cells (HSPCs) remain unclear. In mouse, intra-aortic clusters (IACs) form in the aorta-gonad-mesonephros region and acquire HSPC potential after 9.5 days postcoitum (dpc). In this study we demonstrate that Twist1 is hig...

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Veröffentlicht in:Blood Adv
Hauptverfasser: Kulkeaw, Kasem, Inoue, Tomoko, Iino, Tadafumi, Tani, Kenzaburo, Akashi, Koichi, Speck, Nancy A., Nakanishi, Yoichi, Sugiyama, Daisuke
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2017
Schlagworte:
Hematopoiesis and Stem Cells
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728333/
https://ncbi.nlm.nih.gov/pubmed/29296814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017006056
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