Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms

High-mobility group AT-hook 2 (HMGA2) is crucial for the self-renewal of fetal hematopoietic stem cells (HSCs) but is downregulated in adult HSCs via repression by MIRlet-7 and the polycomb-recessive complex 2 (PRC2) including EZH2. The HMGA2 messenger RNA (mRNA) level is often elevated in patients...

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Pubblicato in:Blood Adv
Autori principali: Ueda, Koki, Ikeda, Kazuhiko, Ikezoe, Takayuki, Harada-Shirado, Kayo, Ogawa, Kazuei, Hashimoto, Yuko, Sano, Takahiro, Ohkawara, Hiroshi, Kimura, Satoshi, Shichishima-Nakamura, Akiko, Nakamura, Yuichi, Shikama, Yayoi, Mori, Tsutomu, Mason, Philip J., Bessler, Monica, Morishita, Soji, Komatsu, Norio, Shide, Kotaro, Shimoda, Kazuya, Koide, Shuhei, Aoyama, Kazumasa, Oshima, Motohiko, Iwama, Atsushi, Takeishi, Yasuchika
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728313/
https://ncbi.nlm.nih.gov/pubmed/29296743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017004457
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