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Evaluation of Mitoquinone for protecting against amikacin-induced ototoxicity in guinea pigs

HYPOTHESIS: Mitoquinone (MitoQ) attenuates amikacin ototoxicity in guinea pigs. BACKGROUND: MitoQ, a mitochondria-targeted derivative of the antioxidant ubiquinone, has improved bioavailability and demonstrated safety in humans. Thus, MitoQ is a promising therapeutic approach for protecting against...

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Detalhes bibliográficos
Publicado no:Otol Neurotol
Main Authors: Dirain, Carolyn O., Ng, Maria Raye Ann V., Milne-Davies, Bailey, Joseph, Jerin K., Antonelli, Patrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728173/
https://ncbi.nlm.nih.gov/pubmed/29194212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MAO.0000000000001638
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