Phase 1 study of the Hedgehog pathway inhibitor sonidegib for steroid-refractory chronic graft-versus-host disease

Hedgehog signaling plays a key role in tissue fibrosis, the pathological hallmark of chronic graft-versus-host disease (cGVHD). We conducted a phase 1 trial of sonidegib, a selective antagonist of the hedgehog coreceptor Smoothened, for the treatment of steroid-refractory cGVHD. After a 3+3 study de...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: DeFilipp, Zachariah, Nazarian, Rosalynn M., El-Jawahri, Areej, Li, Shuli, Brown, Jami, Del Rio, Candice, Smith, Melissa, Valles, Betsy, Ballen, Karen K., McAfee, Steven L., Rosenblatt, Jacalyn, Antin, Joseph H., Cutler, Corey S., Chen, Yi-Bin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728150/
https://ncbi.nlm.nih.gov/pubmed/29296838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017011239
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