Suppression of PTPN6 exacerbates aluminum oxide nanoparticle-induced COPD-like lesions in mice through activation of STAT pathway

BACKGROUND: Inhaled nanoparticles can deposit in the deep lung where they interact with pulmonary cells. Despite numerous studies on pulmonary nanotoxicity, detailed molecular mechanisms of specific nanomaterial-induced lung injury have yet to be identified. RESULTS: Using whole-body dynamic inhalat...

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Detalhes bibliográficos
Publicado no:Part Fibre Toxicol
Main Authors: Li, Xiaobo, Yang, Hongbao, Wu, Shenshen, Meng, Qingtao, Sun, Hao, Lu, Runze, Cui, Jian, Zheng, Yuxin, Chen, Wen, Zhang, Rong, Aschner, Michael, Chen, Rui
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728016/
https://ncbi.nlm.nih.gov/pubmed/29233151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12989-017-0234-0
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