UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis

Uncoupling Protein 1 (UCP1) plays a central role in non-shivering thermogenesis in brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-independent thermogenic mechanism in beige fat that involves enhanced ATP-dependent Ca(2+) cycling by sarco/endoplasmic reticulum...

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Publicat a:Nat Med
Autors principals: Ikeda, Kenji, Kang, Qianqian, Yoneshiro, Takeshi, Camporez, Joao Paulo, Maki, Hiroko, Homma, Mayu, Shinoda, Kosaku, Chen, Yong, Lu, Xiaodan, Maretich, Pema, Tajima, Kazuki, Ajuwon, Kolapo M., Soga, Tomoyoshi, Kajimura, Shingo
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727902/
https://ncbi.nlm.nih.gov/pubmed/29131158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4429
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