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Probing the requirement for CD38 in retinoic acid-induced HL-60 cell differentiation with a small molecule dimerizer and genetic knockout
CD38 is an ectoenzyme and receptor with key physiological roles. It metabolizes NAD(+) to adenosine diphosphate ribose (ADPR) and cyclic ADPR, regulating several processes including calcium signalling. CD38 is both a positive and negative prognostic indicator in leukaemia. In all-trans retinoic acid...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5727258/ https://ncbi.nlm.nih.gov/pubmed/29234114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17720-4 |
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