Hyperbranched poly(ϵ-lysine) substrate presenting the laminin sequence YIGSR induces the formation of spheroids in adult bone marrow stem cells

Unlike the fibroblast-like cells formed upon monolayer culture of human mesenchymal stem cells, the natural stem cell niche of the bone marrow and other types of tissues favours the formation of 3-dimensional (3D) cell clusters. The structuring and biological activity of these clusters are regulated...

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Veröffentlicht in:PLoS One
Hauptverfasser: Perugini, Valeria, Meikle, Steve T., Guildford, Anna L., Santin, Matteo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726715/
https://ncbi.nlm.nih.gov/pubmed/29232694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187182
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