Tyrosine kinase inhibitors impair B-cell immune responses in CML through off-target inhibition of kinases important for cell signaling

Tyrosine kinase inhibitors (TKIs) have significant off-target multikinase inhibitory effects. We aimed to study the impact of TKIs on the in vivo B-cell response to vaccination. Cellular and humoral responses to influenza and pneumococcal vaccines were evaluated in 51 chronic phase chronic myeloid l...

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Gepubliceerd in:Blood
Hoofdauteurs: de Lavallade, Hugues, Khoder, Ahmad, Hart, Melanie, Sarvaria, Anushruti, Sekine, Takuya, Alsuliman, Abdullah, Mielke, Stephan, Bazeos, Alexandra, Stringaris, Kate, Ali, Sara, Milojkovic, Dragana, Foroni, Letizia, Chaidos, Aristeidis, Cooper, Nichola, Gabriel, Ian, Apperley, Jane, Belsey, Sarah, Flanagan, Robert J., Goldman, John, Shpall, Elizabeth J., Kelleher, Peter, Marin, David, Rezvani, Katayoun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2013
Onderwerpen:
Myeloid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726329/
https://ncbi.nlm.nih.gov/pubmed/23719297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-11-465039
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