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Manipulation of both virus- and cell-specific factors is required for robust transient replication of a hepatitis C virus genotype 3a sub-genomic replicon

Hepatitis C virus (HCV) genotype (GT) 3 is the second most prevalent of the seven HCV genotypes and exhibits the greatest resistance to the highly potent, direct-acting antivirals (DAAs) that are currently in use. Previously a stable cell line harbouring the S52 GT3 sub-genomic replicon (SGR) was es...

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Pubblicato in:J Gen Virol
Autori principali: Kelly, Lorna, Badhan, Anjna, Roberts, Grace C., Mbisa, Jean Lutamyo, Harris, Mark
Natura: Artigo
Lingua:Inglês
Pubblicazione: Microbiology Society 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725995/
https://ncbi.nlm.nih.gov/pubmed/28984238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jgv.0.000932
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