Microglial dysfunction as a key pathological change in adrenomyeloneuropathy

OBJECTIVE: Mutations in ABCD1 cause the neurodegenerative disease, adrenoleukodystrophy, which manifests as the spinal cord axonopathy adrenomyeloneuropathy (AMN) in nearly all males surviving into adulthood. Microglial dysfunction has long been implicated in pathogenesis of brain disease, but its r...

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Vydáno v:Ann Neurol
Hlavní autoři: Gong, Yi, Sasidharan, Nikhil, Laheji, Fiza, Frosch, Matthew, Musolino, Patricia, Tanzi, Rudy, Kim, Doo Yeon, Biffi, Alessandra, El Khoury, Joseph, Eichler, Florian
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725816/
https://ncbi.nlm.nih.gov/pubmed/29059709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25085
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