Mutual independence of alkaline‐ and calcium‐mediated signalling in Aspergillus fumigatus refutes the existence of a conserved druggable signalling nexus

Functional coupling of calcium‐ and alkaline responsive signalling occurs in multiple fungi to afford efficient cation homeostasis. Host microenvironments exert alkaline stress and potentially toxic concentrations of Ca(2+), such that highly conserved regulators of both calcium‐ (Crz) and pH‐ (PacC/...

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Detalhes bibliográficos
Publicado no:Mol Microbiol
Main Authors: Loss, Omar, Bertuzzi, Margherita, Yan, Yu, Fedorova, Natalie, McCann, Bethany L., Armstrong‐James, Darius, Espeso, Eduardo A., Read, Nick D., Nierman, William C., Bignell, Elaine M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725717/
https://ncbi.nlm.nih.gov/pubmed/28922497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13840
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