Transiently expressed ATG16L1 inhibits autophagosome biogenesis and aberrantly targets RAB11-positive recycling endosomes

The membrane source for autophagosome biogenesis is an unsolved mystery in the study of autophagy. ATG16L1 forms a complex with ATG12–ATG5 (the ATG16L1 complex). The ATG16L1 complex is recruited to autophagic membranes to convert MAP1LC3B-I to MAP1LC3B-II. The ATG16L1 complex dissociates from the ph...

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Bibliografiske detaljer
Udgivet i:Autophagy
Main Authors: Li, Jiehua, Chen, Zhixia, Stang, Michael T., Gao, Wentao
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Basic Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724932/
https://ncbi.nlm.nih.gov/pubmed/27875067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1256521
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