Mycobacterial infection induces higher interleukin-1β and dysregulated lung inflammation in mice with defective leukocyte NADPH oxidase

Granulomatous inflammation causes severe tissue damage in mycobacterial infection while redox status was reported to be crucial in the granulomatous inflammation. Here, we used a NADPH oxidase 2 (NOX2)-deficient mice (Ncf1(-/-)) to investigate the role of leukocyte-produced reactive oxygen species (...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Chao, Wen-Cheng, Yen, Chia-Liang, Hsieh, Cheng-Yuan, Huang, Ya-Fang, Tseng, Yau-Lin, Nigrovic, Peter Andrija, Shieh, Chi-Chang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724816/
https://ncbi.nlm.nih.gov/pubmed/29228045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189453
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