TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, randomised controlled trial

BACKGROUND: For children with sickle cell anaemia and elevated transcranial Doppler (TCD) flow velocities, regular blood transfusions effectively prevent primary stroke, but must be continued indefinitely. The efficacy of hydroxyurea in this setting is unknown. METHODS: TWiTCH was a multicentre Phas...

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Publicado no:Lancet
Main Authors: Ware, Russell E., Davis, Barry R., Schultz, William H., Brown, R. Clark, Aygun, Banu, Sarnaik, Sharada, Odame, Isaac, Fuh, Beng, George, Alex, Owen, William, Luchtman-Jones, Lori, Rogers, Zora R., Hilliard, Lee, Gauger, Cynthia, Piccone, Connie, Lee, Margaret T., Kwiatkowski, Janet L., Jackson, Sherron, Miller, Scott T., Roberts, Carla, Heeney, Matthew M., Kalfa, Theodosia A., Nelson, Stephen, Imran, Hamayun, Nottage, Kerri, Alvarez, Ofelia, Rhodes, Melissa, Thompson, Alexis A., Rothman, Jennifer A., Helton, Kathleen J., Roberts, Donna, Coleman, Jamie, Bonner, Melanie J., Kutlar, Abdullah, Patel, Niren, Wood, John, Piller, Linda, Wei, Peng, Luden, Judy, Mortier, Nicole A., Stuber, Susan E., Luban, Naomi L. C., Cohen, Alan R., Pressel, Sara, Adams, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724392/
https://ncbi.nlm.nih.gov/pubmed/26670617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(15)01041-7
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