TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, randomised controlled trial

BACKGROUND: For children with sickle cell anaemia and elevated transcranial Doppler (TCD) flow velocities, regular blood transfusions effectively prevent primary stroke, but must be continued indefinitely. The efficacy of hydroxyurea in this setting is unknown. METHODS: TWiTCH was a multicentre Phas...

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Udgivet i:Lancet
Main Authors: Ware, Russell E., Davis, Barry R., Schultz, William H., Brown, R. Clark, Aygun, Banu, Sarnaik, Sharada, Odame, Isaac, Fuh, Beng, George, Alex, Owen, William, Luchtman-Jones, Lori, Rogers, Zora R., Hilliard, Lee, Gauger, Cynthia, Piccone, Connie, Lee, Margaret T., Kwiatkowski, Janet L., Jackson, Sherron, Miller, Scott T., Roberts, Carla, Heeney, Matthew M., Kalfa, Theodosia A., Nelson, Stephen, Imran, Hamayun, Nottage, Kerri, Alvarez, Ofelia, Rhodes, Melissa, Thompson, Alexis A., Rothman, Jennifer A., Helton, Kathleen J., Roberts, Donna, Coleman, Jamie, Bonner, Melanie J., Kutlar, Abdullah, Patel, Niren, Wood, John, Piller, Linda, Wei, Peng, Luden, Judy, Mortier, Nicole A., Stuber, Susan E., Luban, Naomi L. C., Cohen, Alan R., Pressel, Sara, Adams, Robert J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724392/
https://ncbi.nlm.nih.gov/pubmed/26670617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(15)01041-7
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