Cancer cells induce interleukin-22 production from memory CD4(+) T cells via interleukin-1 to promote tumor growth

IL-22 has been identified as a cancer-promoting cytokine that is secreted by infiltrating immune cells in several cancer models. We hypothesized that IL-22 regulation would occur at the interface between cancer cells and immune cells. Breast and lung cancer cells of murine and human origin induced I...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Voigt, Cornelia, May, Peter, Gottschlich, Adrian, Markota, Anamarija, Wenk, Daniel, Gerlach, Inga, Voigt, Sebastian, Stathopoulos, Georgios T., Arendt, Kristina A. M., Heise, Constanze, Rataj, Felicitas, Janssen, Klaus-Peter, Königshoff, Melanie, Winter, Hauke, Himsl, Isabelle, Thasler, Wolfgang E., Schnurr, Max, Rothenfußer, Simon, Endres, Stefan, Kobold, Sebastian
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724250/
https://ncbi.nlm.nih.gov/pubmed/29150554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705165114
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