Protein misfolding, amyotrophic lateral sclerosis and guanabenz: protocol for a phase II RCT with futility design (ProMISe trial)

INTRODUCTION: Recent studies suggest that endoplasmic reticulum stress may play a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS) through an altered regulation of the proteostasis, the cellular pathway-balancing protein synthesis and degradation. A key mechanism is thought t...

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Detalhes bibliográficos
Publicado no:BMJ Open
Main Authors: Bella, Eleonora Dalla, Tramacere, Irene, Antonini, Giovanni, Borghero, Giuseppe, Capasso, Margherita, Caponnetto, Claudia, Chiò, Adriano, Corbo, Massimo, Eleopra, Roberto, Filosto, Massimiliano, Giannini, Fabio, Granieri, Enrico, Bella, Vincenzo La, Lunetta, Christian, Mandrioli, Jessica, Mazzini, Letizia, Messina, Sonia, Monsurrò, Maria Rosaria, Mora, Gabriele, Riva, Nilo, Rizzi, Romana, Siciliano, Gabriele, Silani, Vincenzo, Simone, Isabella, Sorarù, Gianni, Volanti, Paolo, Lauria, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2017
Assuntos:
Neurology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724081/
https://ncbi.nlm.nih.gov/pubmed/28801400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2016-015434
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