Sustained Release of a Peptide-based Matrix Metalloproteinase-2 Inhibitor to Attenuate Adverse Cardiac Remodeling and Improve Cardiac Function Following Myocardial Infarction

Following myocardial infarction (MI), degradation of extracellular matrix (ECM) by upregulated matrix metalloproteinases (MMPs) especially MMP-2 decreases tissue mechanical properties, leading to cardiac function deterioration. Attenuation of cardiac ECM degradation at the early stage of MI has the...

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Pubblicato in:Biomacromolecules
Autori principali: Fan, Zhaobo, Fu, Minghuan, Xu, Zhaobin, Zhang, Bo, Li, Zhihong, Li, Haichang, Zhou, Xinyu, Liu, Xuanyou, Duan, Yunyan, Lin, Pei-Hui, Duann, Pu, Xie, Xiaoyun, Ma, Jianjie, Liu, Zhenguo, Guan, Jianjun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5723129/
https://ncbi.nlm.nih.gov/pubmed/28731675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biomac.7b00760
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