Virtual screening for inhibitors of the human TSLP:TSLPR interaction

The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) plays a pivotal role in the pathophysiology of various allergy disorders that are mediated by type 2 helper T cell (Th2) responses, such as asthma and atopic dermatitis. TSLP forms a ternary complex with the TSLP receptor (TSLPR) and...

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Vydáno v:Sci Rep
Hlavní autoři: Van Rompaey, Dries, Verstraete, Kenneth, Peelman, Frank, Savvides, Savvas N., Augustyns, Koen, Van Der Veken, Pieter, De Winter, Hans
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722893/
https://ncbi.nlm.nih.gov/pubmed/29222519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17620-7
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