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Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice

Ancestral environmental exposures to non-mutagenic agents can exert effects in unexposed descendants. This transgenerational inheritance has significant implications for understanding disease etiology. Here we show that exposure of F0 mice to the obesogen tributyltin (TBT) throughout pregnancy and l...

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Publicado en:Nat Commun
Main Authors: Chamorro-Garcia, Raquel, Diaz-Castillo, Carlos, Shoucri, Bassem M., Käch, Heidi, Leavitt, Ron, Shioda, Toshi, Blumberg, Bruce
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722856/
https://ncbi.nlm.nih.gov/pubmed/29222412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01944-z
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