Thrombomodulin favors leukocyte microvesicle fibrinolytic activity, reduces NETosis and prevents septic shock-induced coagulopathy in rats

BACKGROUND: Septic shock-induced disseminated intravascular coagulation is responsible for increased occurrence of multiple organ dysfunction and mortality. Immunothrombosis-induced coagulopathy may contribute to hypercoagulability. We aimed at determining whether recombinant human thrombomodulin (r...

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Vydáno v:Ann Intensive Care
Hlavní autoři: Helms, Julie, Clere-Jehl, Raphaël, Bianchini, Elsa, Le Borgne, Pierrick, Burban, Mélanie, Zobairi, Fatiha, Diehl, Jean-Luc, Grunebaum, Lelia, Toti, Florence, Meziani, Ferhat, Borgel, Delphine
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722785/
https://ncbi.nlm.nih.gov/pubmed/29222696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13613-017-0340-z
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