Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels

The cis benzopyran compound tonabersat (SB-220453) has previously been reported to inhibit connexin26 expression in the brain by attenuating the p38-mitogen-activated protein kinase pathway. We show here that tonabersat directly inhibits connexin43 hemichannel opening. Connexin43 hemichannels have b...

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Vydáno v:Neurotherapeutics
Hlavní autoři: Kim, Yeri, Griffin, Jarred M., Nor, Mohd N. Mat, Zhang, Jie, Freestone, Peter S., Danesh-Meyer, Helen V., Rupenthal, Ilva D., Acosta, Monica, Nicholson, Louise F. B., O’Carroll, Simon J., Green, Colin R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722754/
https://ncbi.nlm.nih.gov/pubmed/28560708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-017-0536-9
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