Dual effects of radiation bystander signaling in urothelial cancer: purinergic-activation of apoptosis attenuates survival of urothelial cancer and normal urothelial cells

Radiation therapy (RT) delivers tumour kill, directly and often via bystander mechanisms. Bladder toxicity is a dose limiting constraint in pelvic RT, manifested as radiation cystitis and urinary symptoms. We aimed to investigate the impact of radiation-induced bystander signaling on normal/cancer u...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Bill, Malgorzata A., Srivastava, Kirtiman, Breen, Conor, Butterworth, Karl T., McMahon, Stephen J., Prise, Kevin M., McCloskey, Karen D.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722566/
https://ncbi.nlm.nih.gov/pubmed/29228614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21995
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