Chronic myeloid leukemia progenitor cells require autophagy when leaving hypoxia-induced quiescence

Albeit tyrosine kinase inhibitors anti-Abl used in Chronic Myeloid Leukemia (CML) block the deregulated activity of the Bcr-Abl tyrosine kinase and induce remission in 90% of patients, they do not eradicate immature hematopoietic compartments of leukemic stem cells. To elucidate if autophagy is impo...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ianniciello, Angela, Dumas, Pierre-Yves, Drullion, Claire, Guitart, Amélie, Villacreces, Arnaud, Peytour, Yan, Chevaleyre, Jean, Brunet de la Grange, Philippe, Vigon, Isabelle, Desplat, Vanessa, Priault, Muriel, Sbarba, Persio Dello, Ivanovic, Zoran, Mahon, François-Xavier, Pasquet, Jean-Max
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722539/
https://ncbi.nlm.nih.gov/pubmed/29228587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18904
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