Synthesis of novel purpurealidin analogs and evaluation of their effect on the cancer-relevant potassium channel K(V)10.1

In the search for novel anticancer drugs, the potassium channel K(V)10.1 has emerged as an interesting cancer target. Here, we report a new group of K(V)10.1 inhibitors, namely the purpurealidin analogs. These alkaloids are produced by the Verongida sponges and are known for their wide variety of bi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Moreels, Lien, Bhat, Chinmay, Voráčová, Manuela, Peigneur, Steve, Goovaerts, Hannah, Mäki-Lohiluoma, Eero, Zahed, Farrah, Pardo, Luis A., Yli-Kauhaluoma, Jari, Kiuru, Paula, Tytgat, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722316/
https://ncbi.nlm.nih.gov/pubmed/29220359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188811
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