Targeting the cross-talk between Urokinase receptor and Formyl peptide receptor type 1 to prevent invasion and trans-endothelial migration of melanoma cells

BACKGROUND: Accumulating evidence demonstrates that the Urokinase Receptor (uPAR) regulates tumor cell migration through its assembly in composite regulatory units with transmembrane receptors, and uPAR(88–92) is the minimal sequence required to induce cell motility through the Formyl Peptide Recept...

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Veröffentlicht in:J Exp Clin Cancer Res
Hauptverfasser: Ragone, Concetta, Minopoli, Michele, Ingangi, Vincenzo, Botti, Giovanni, Fratangelo, Federica, Pessi, Antonello, Stoppelli, Maria Patrizia, Ascierto, Paolo Antonio, Ciliberto, Gennaro, Motti, Maria Letizia, Carriero, Maria Vincenza
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5721612/
https://ncbi.nlm.nih.gov/pubmed/29216889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0650-x
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