MicroRNA therapy inhibits hepatoblastoma growth in vivo by targeting β‐catenin and Wnt signaling

Hepatoblastoma (HBL) is the most common pediatric liver cancer. In this malignant neoplasm, beta‐catenin protein accumulates and increases Wnt signaling due to recurrent activating mutations in the catenin‐beta 1 (CTNNB1) gene. Therefore, beta‐catenin is a key therapeutic target in HBL. However, con...

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Bibliografiske detaljer
Udgivet i:Hepatol Commun
Main Authors: Indersie, Emilie, Lesjean, Sarah, Hooks, Katarzyna B., Sagliocco, Francis, Ernault, Tony, Cairo, Stefano, Merched‐Sauvage, Maria, Rullier, Anne, Le Bail, Brigitte, Taque, Sophie, Grotzer, Michael, Branchereau, Sophie, Guettier, Catherine, Fabre, Monique, Brugières, Laurence, Hagedorn, Martin, Buendia, Marie‐Annick, Grosset, Christophe F.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5721429/
https://ncbi.nlm.nih.gov/pubmed/29404451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1029
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