HCV kinetic and modeling analyses project shorter durations to cure under combined therapy with daclatasvir and asunaprevir in chronic HCV-infected patients

BACKGROUND & AIMS: High cure rates are achieved in HCV genotype-1b patients treated with daclatasvir and asunaprevir, DCV/ASV. Here we analyzed early HCV kinetics in genotype-1b infected Japanese subjects treated with DCV/ASV and retrospectively projected, using mathematical modeling, whether sh...

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Veröffentlicht in:PLoS One
Hauptverfasser: Canini, Laetitia, Imamura, Michio, Kawakami, Yoshiiku, Uprichard, Susan L., Cotler, Scott J., Dahari, Harel, Chayama, Kazuaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720697/
https://ncbi.nlm.nih.gov/pubmed/29216198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187409
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