Voltage-dependent calcium channel signaling mediates GABA(A) receptor-induced migratory activation of dendritic cells infected by Toxoplasma gondii

The obligate intracellular parasite Toxoplasma gondii exploits cells of the immune system to disseminate. Upon T. gondii-infection, γ–aminobutyric acid (GABA)/GABA(A) receptor signaling triggers a hypermigratory phenotype in dendritic cells (DCs) by unknown signal transduction pathways. Here, we dem...

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Pubblicato in:PLoS Pathog
Autori principali: Kanatani, Sachie, Fuks, Jonas M., Olafsson, Einar B., Westermark, Linda, Chambers, Benedict, Varas-Godoy, Manuel, Uhlén, Per, Barragan, Antonio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720541/
https://ncbi.nlm.nih.gov/pubmed/29216332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006739
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