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EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

The success of anticancer therapy is usually limited by the development of drug resistance. Such acquired resistance is driven, in part, by intratumoural heterogeneity — that is, the phenotypic diversity of cancer cells co-inhabiting a single tumour mass. The introduction of the cancer stem cell (CS...

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Détails bibliographiques
Publié dans:Nat Rev Clin Oncol
Auteurs principaux: Shibue, Tsukasa, Weinberg, Robert A.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720366/
https://ncbi.nlm.nih.gov/pubmed/28397828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrclinonc.2017.44
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