The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases

Microglia play a pivotal role in maintenance of brain homeostasis, but lose homeostatic function during neurodegenerative disorders. We identified a specific apolipoprotein E (APOE)-dependent molecular signature in microglia from models of amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS)...

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Publicat a:Immunity
Autors principals: Krasemann, Susanne, Madore, Charlotte, Cialic, Ron, Baufeld, Caroline, Calcagno, Narghes, El Fatimy, Rachid, Beckers, Lien, O’Loughlin, Elaine, Xu, Yang, Fanek, Zain, Greco, David J., Smith, Scott T., Tweet, George, Humulock, Zachary, Zrzavy, Tobias, Conde-Sanroman, Patricia, Gacias, Mar, Weng, Zhiping, Chen, Hao, Tjon, Emily, Mazaheri, Fargol, Hartmann, Kristin, Madi, Asaf, Ulrich, Jason, Glatzel, Markus, Worthmann, Anna, Heeren, Joerg, Budnik, Bogdan, Lemere, Cynthia, Ikezu, Tsuneya, Heppner, Frank L., Litvak, Vladimir, Holtzman, David M., Lassmann, Hans, Weiner, Howard L., Ochando, Jordi, Haass, Christian, Butovsky, Oleg
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719893/
https://ncbi.nlm.nih.gov/pubmed/28930663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.08.008
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