Design and synthesis of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-2H-1,2,3-triazole derivatives as colchicine binding site inhibitors

A series of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-2H-1,2,3-triazol derivatives were designed as potential microtubule targeting agents. The regioselective alkylation of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-2H-1,2,3-triazole was predicted by computations and confirmed by an unambiguous synthetic r...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wu, Yue, Feng, Dongjie, Gao, Meiqi, Wang, Zhiwei, Yan, Peng, Gu, Zhenzhen, Guan, Qi, Zuo, Daiying, Bao, Kai, Sun, Jun, Wu, Yingliang, Zhang, Weige
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719359/
https://ncbi.nlm.nih.gov/pubmed/29215079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17449-0
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