Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

STING is an innate immune cytosolic adaptor for DNA sensors that engage malaria parasite (Plasmodium falciparum) or other pathogen DNA. As P. falciparum infects red blood cells and not leukocytes, how parasite DNA reaches such host cytosolic DNA sensors in immune cells is unclear. Here we show that...

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出版年:Nat Commun
主要な著者: Sisquella, Xavier, Ofir-Birin, Yifat, Pimentel, Matthew A., Cheng, Lesley, Abou Karam, Paula, Sampaio, Natália G., Penington, Jocelyn Sietsma, Connolly, Dympna, Giladi, Tal, Scicluna, Benjamin J., Sharples, Robyn A., Waltmann, Andreea, Avni, Dror, Schwartz, Eli, Schofield, Louis, Porat, Ziv, Hansen, Diana S., Papenfuss, Anthony T., Eriksson, Emily M., Gerlic, Motti, Hill, Andrew F., Bowie, Andrew G., Regev-Rudzki, Neta
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719353/
https://ncbi.nlm.nih.gov/pubmed/29215015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02083-1
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