Glucuronidation of deoxynivalenol (DON) by different animal species: identification of iso-DON glucuronides and iso-deepoxy-DON glucuronides as novel DON metabolites in pigs, rats, mice, and cows

The Fusarium mycotoxin deoxynivalenol (DON) is a frequent contaminant of cereal-based food and feed. Mammals metabolize DON by conjugation to glucuronic acid (GlcAc), the extent and regioselectivity of which is species-dependent. So far, only DON-3-glucuronide (DON-3-GlcAc) and DON-15-GlcAc have bee...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Schwartz-Zimmermann, Heidi E., Hametner, Christian, Nagl, Veronika, Fiby, Iris, Macheiner, Lukas, Winkler, Janine, Dänicke, Sven, Clark, Erica, Pestka, James J., Berthiller, Franz
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2017
Assuntos:
Toxicokinetics and Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719127/
https://ncbi.nlm.nih.gov/pubmed/28638985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-017-2012-z
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