Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

Mechanisms of acquired resistance to immune checkpoint inhibitors (ICIs) are poorly understood. We leveraged a collection of 14 ICI-resistant lung cancer samples to investigate whether alterations in genes encoding HLA Class I antigen processing and presentation machinery (APM) components or interfe...

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Veröffentlicht in:Cancer Discov
Hauptverfasser: Gettinger, Scott, Choi, Jungmin, Hastings, Katherine, Truini, Anna, Datar, Ila, Sowell, Ryan, Wurtz, Anna, Dong, Weilai, Cai, Guoping, Ann Melnick, Mary, Du, Victor Y., Schlessinger, Joseph, Goldberg, Sarah B., Chiang, Anne, Sanmamed, Miguel F., Melero, Ignacio, Agorreta, Jackeline, Montuenga, Luis, Lifton, Richard, Ferrone, Soldano, Kavathas, Paula, Rimm, David L., Kaech, Susan M., Schalper, Kurt, Herbst, Roy S., Politi, Katerina
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718941/
https://ncbi.nlm.nih.gov/pubmed/29025772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-0593
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