A simulation study on the impact of the blood flow-dependent component in [(18)F]AV45 SUVR in Alzheimer’s disease

BACKGROUND: Increased brain uptake on [(18)F]AV45 PET is a biomarker for Alzheimer’s disease (AD). The standardised uptake value ratio (SUVR) is widely used for quantification but is subject to variability. Here we evaluate how SUVR of a cortical target region is affected by blood flow changes in th...

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Pubblicato in:PLoS One
Autori principali: Ottoy, Julie, Verhaeghe, Jeroen, Niemantsverdriet, Ellis, Engelborghs, Sebastiaan, Stroobants, Sigrid, Staelens, Steven
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718604/
https://ncbi.nlm.nih.gov/pubmed/29211812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189155
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