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Heterodimeric interaction between GKN2 and TFF1 entails synergistic antiproliferative and pro-apoptotic effects on gastric cancer cells

BACKGROUND: GKN2 and TFF1 form a heterodimer that is only generated in the mucus-secreting cells of the normal stomach. The formation of this heterodimer is frequently disrupted in gastric cancer. However, the precise roles of GKN2 alone and in the heterodimer with TFF1 as well as the contributions...

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Detalhes bibliográficos
Publicado no:Gastric Cancer
Main Authors: Kim, Olga, Yoon, Jung Hwan, Choi, Won Suk, Ashktorab, Hassan, Smoot, Duane T., Nam, Suk Woo, Lee, Jung Young, Park, Won Sang
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718056/
https://ncbi.nlm.nih.gov/pubmed/28150071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10120-017-0692-y
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