Heterodimeric interaction between GKN2 and TFF1 entails synergistic antiproliferative and pro-apoptotic effects on gastric cancer cells

BACKGROUND: GKN2 and TFF1 form a heterodimer that is only generated in the mucus-secreting cells of the normal stomach. The formation of this heterodimer is frequently disrupted in gastric cancer. However, the precise roles of GKN2 alone and in the heterodimer with TFF1 as well as the contributions...

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Pubblicato in:Gastric Cancer
Autori principali: Kim, Olga, Yoon, Jung Hwan, Choi, Won Suk, Ashktorab, Hassan, Smoot, Duane T., Nam, Suk Woo, Lee, Jung Young, Park, Won Sang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718056/
https://ncbi.nlm.nih.gov/pubmed/28150071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10120-017-0692-y
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