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Multiple steady states and the form of response functions to antigen in a model for the initiation of T-cell activation

The aim of this paper is to study the qualitative behaviour predicted by a mathematical model for the initial stage of T-cell activation. The state variables in the model are the concentrations of phosphorylation states of the T-cell receptor (TCR) complex and the phosphatase SHP-1 in the cell. It i...

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Detalhes bibliográficos
Publicado no:R Soc Open Sci
Main Authors: Rendall, Alan D., Sontag, Eduardo D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society Publishing 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5717646/
https://ncbi.nlm.nih.gov/pubmed/29291072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsos.170821
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