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Stable Chromosomal Expression of Shigella flexneri 2a and 3a O-Antigens in the Live Salmonella Oral Vaccine Vector Ty21a

We have been exploring the use of the live attenuated Salmonella enterica serovar Typhi Ty21a vaccine strain as a versatile oral vaccine vector for the expression and delivery of multiple foreign antigens, including Shigella O-antigens. In this study, we separately cloned genes necessary for the bio...

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Détails bibliographiques
Publié dans:Clin Vaccine Immunol
Auteurs principaux: Dharmasena, Madushini N., Osorio, Manuel, Takeda, Kazuyo, Stibitz, Scott, Kopecko, Dennis J.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5717188/
https://ncbi.nlm.nih.gov/pubmed/29046309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00181-17
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